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Botox vs Xeomin: Understanding the Difference

When you decide to enhance your appearance using non-surgical treatments, two emerge as the most popular options. This is particularly for minimizing wrinkles and achieving a more youthful appearance

They are Botox and Xeomin.

While both fall under the category of neurotoxin injectables and share the goal of reducing facial lines, they have subtle differences that can impact a patient’s choice.

In this comprehensive guide, we’ll delve into the distinctions between Botox and Xeomin, exploring their mechanisms, applications, and considerations for individuals seeking these cosmetic treatments.

The Basics of Botox and Xeomin

Let’s get started with the basics. What do you need to know before you start considering the two options?


Botox, short for Botulinum Toxin Type A, is one of the most well-known and widely used cosmetic injectables. It is derived from the bacterium Clostridium botulinum and works by temporarily paralyzing or relaxing targeted muscles.

By inhibiting muscle contractions, Botox injections soften the appearance of dynamic wrinkles, particularly those caused by repetitive facial movements like frowning or squinting. Botox has been approved by the U.S. Food and Drug Administration (FDA) for various cosmetic and medical applications.


Xeomin, like Botox, is also a neurotoxin injectable. However, it is derived from a slightly different strain of bacteria, Clostridium botulinum type A.

The key distinction lies in its “naked” formulation, meaning it lacks the complexing proteins present in Botox.

It is designed to address dynamic wrinkles in a manner similar to Botox, temporarily relaxing targeted muscles. It received FDA approval for cosmetic use in the United States and is recognized for its efficacy in treating facial lines.

Formulation Differences

As you might imagine, both of these injectables are formulated slightly differently. It might be a bit technical, but let’s see how they differ in their chemical formulation.


The formulation of Botox includes the active Botulinum Toxin Type A and complexing proteins. These proteins are believed to play a role in the overall stability and effectiveness of the product. While Botox’s complexing proteins may contribute to its potency, they could also increase the likelihood of an immune response in some individuals.


Xeomin, in contrast, is formulated with a “naked” or purified version of Botulinum Toxin Type A, devoid of complexing proteins. This feature can be advantageous for patients concerned about potential immune reactions or resistance to neurotoxin treatments. Xeomin’s naked formulation means the body is less likely to develop antibodies against the neurotoxin.

Onset and Duration of Results

Both these formulations do have a slightly different effect on the body. This is something to consider, especially if you are slightly impatient about seeing results.


Patients typically begin to notice the effects of Botox within a few days, with full results becoming evident over the course of one to two weeks. The duration of the effects can vary but often lasts for approximately three to four months. Subsequent treatments are required to maintain the desired results.


Xeomin’s onset of action is similar to that of Botox, with visible results appearing within a week or two after treatment. The duration of Xeomin’s effects is also comparable, generally lasting around three to four months. Like Botox, repeated treatments are necessary for ongoing wrinkle reduction.

Considerations for Choosing Between Botox and Xeomin

It’s not so simple, as you can see, to choose between Botox and Xeomin. There are certain considerations you should absolutely keep in mind when making the choice. They are:


The issue of immunogenicity, or the development of antibodies against the neurotoxin, is a consideration for some patients. As Botox contains complexing proteins, there is a theoretical risk that the body may recognize these proteins as foreign, leading to the formation of antibodies.

Xeomin’s naked formulation reduces this risk, potentially making it a preferred option for individuals concerned about developing resistance to the treatment.

Personal Preferences

Patient preferences, including their response to previous treatments and individual sensitivities, can influence the choice between Botox and Xeomin. Some individuals may find one product more suitable for their needs based on factors such as perceived comfort during injection or the longevity of results.

Cost Considerations

Cost can be a factor when choosing between Botox and Xeomin. While prices can vary based on geographical location and the healthcare provider, some individuals may find one product more cost-effective than the other. Patients need to discuss pricing and potential discounts with their chosen provider.

Provider Expertise

The experience and expertise of the healthcare provider administering the treatment are crucial. Both Botox and Xeomin require skillful injection techniques to achieve natural-looking results. Choosing a qualified and experienced practitioner familiar with both products is essential for a successful outcome.

Safety and Side Effects

Even though these formulations aren’t necessarily a surgical treatment, they still come with their own side effects. Don’t jump into them without doing some research and having a serious consultation with an expert. 


Botox has a long-established safety record and is considered a generally safe and well-tolerated cosmetic treatment. Common side effects are typically mild and temporary, including bruising, swelling, and redness at the injection site. Serious complications are rare when administered by a qualified professional.


Xeomin shares a similar safety profile with Botox. As with any injectable treatment, patients may experience temporary side effects like bruising, swelling, or discomfort at the injection site.

Adverse reactions are infrequent. This is especially true when a skilled and experienced practitioner performs the treatment.

Who Doesn’t Want More Youthful Skin Even as They Age?

Age is just a number nowadays. In a lot of cases, due to all the different treatments available, you can’t tell what someone’s chronological age is.

And that’s a great thing for anyone looking to gain more youthful skin. Both Botox and Xeomin are skin treatments that can potentially be part of your self-care routine. 

Don’t know which one to choose? Contact DermAesthetics, Northern Kentucy’s choice for dermatological treatments, and get expert feedback on your specific case. We do Botox and Xeomin, fillers, laser treatments, sclerotherapy, chemical peels, and more.